What is one of the major side effects associated with NSAIDs?

One of the major side effects associated with non-steroidal anti-inflammatory drugs (NSAIDs) is stomach ulcers or gastrointestinal bleeding. This occurs because NSAIDs can inhibit the production of prostaglandins, which are compounds that help protect the stomach lining from the harsh effects of gastric acid. When these protective prostaglandins are reduced, the stomach becomes more susceptible to irritation and damage, leading to the development of ulcers or gastrointestinal bleeding, particularly with prolonged use or at higher dosages.

This side effect is significant as it can lead to severe health complications, such as perforation of the stomach or intestines and increased risk of hospitalization. Individuals taking NSAIDs, especially those with pre-existing conditions (like peptic ulcers or gastrointestinal disorders), should be monitored closely. Thus, recognizing the potential for these gastrointestinal issues is crucial when prescribing NSAIDs.